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While lower-depend MBL almost never progresses to CLL, substantial-count MBL progresses to CLL demanding therapy in a fee of one% to 2% per year. Significant-depend MBL is distinguished from Rai 0 CLL determined by whether the B-mobile rely is previously mentioned or under 5 × 109/L. Though men and women with both of those high-rely MBL and CLL Ra